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Transforming growth factor-beta1 induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells

: Reimann, T.; Hempel, U.; Krautwald, S.; Axmann, A.; Scheibe, R.; Seidel, D.; Wenzel, K.-W.


FEBS Letters 403 (1997), S.57-60
ISSN: 0014-5793
ISSN: 1873-3468
Fraunhofer ITA ( ITEM) ()
cell culture; cytology; immunology; Kupffer cells; Liver cells; Mitogens; molecular biology; protein kinase; Ras oncogenes; rat; signal transduction; Transforming growth factors

The transdifferentiation of hepatic stellate cells into myofibroblast-like cells and the proliferation of the transdifferentiated cells are controlled by TGF-ß1. Little is known about the intracellular signal transducers of TGF-ß1. In this paper we show that in cultured hepatic stellate cells TGF-ß1 induces activation of Ras, Raf-1, MEK and MAPK p42 and p44. The activation of MAPK depends on the activation of MEK. Our data exclude that the observed effects are mediated by a bFGF or PDGF autocrine loop.