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Title
Superpotente humane Calcitonin-Analoga mit stark erhoehter hypocalcaemischer Wirkung in vivo
Date Issued
2001
Author(s)
Patent No
1997-19736457
Abstract
NOVELTY - Superpotent human calcitonin analogues which exhibit a much increased hypocalcemic activity in vivo are new. DETAILED DESCRIPTION - Calcitonin and calcitonin derivatives comprising a bridge between the amino acids at positions 17 and 21 in the corresponding human calcitonin forming an 18 or 19 membered ring. USE - The calcitonin analogs are useful for lowering calcium levels and especially for treating osteoporosis, Paget's disease and hypercalcemia. ACTIVITY - Hypocalcemic. MECHANISM OF ACTIVITY - Calcium release inhibitor. ADVANTAGE - A 1000 fold increase in activity compared to human calcitonin is observed in in vivo tests in mice.
Language
de
Patenprio
DE 1997-19736457 A: 19970821