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A subchronic inhalation study of a special test toner in rats.

Eine subchronische Inhalationsstudie mit einem Test-Toner an Ratten
: Kilpper, R.; Creutzenberg, O.; Mermelstein, R.; Mohr, U.; Muhle, H.; Takenaka, S.

The Toxicologist 8 (1988), Nr.1, S.68
ISSN: 0731-9193
Society of Toxicology (Annual Meeting) <27, 1988, Dallas/Tex.>
Fraunhofer ITA ( ITEM) ()
Inhalation; Lunge; Toner für Kopiermaschinen; Toxikologie

A subchronic inhalation study, using SPF, F-344 rats, was conducted for 6 hr/da, 5 da/wk for 13 weeks. The special test toner was enriched about 10-fold, respirably (ACGIH), relative to product. Nominal exposure levels were 0, 1.0, 4.0, 16.0 and 64 mg/cubic meter (0, 0.35, 1.4, 5.6 and 22.4 mg/cubic meter, respirable). The exposures were well-tolerated, with no unscheduled deaths. Significant findings were restricted to the high exposure groups. The MTD (pulmonary) was determined relative to a defined Maximum Functionally Tolerated Dose (MFTD). At the lower exposures, clearance measurements of toner and a spike of iron oxide (Fe-59) were essentially unchanged from controls. At 16 mg/cubic meter, slight effects were observed. At 64 mg/cubic meter, no appreciable toner clearance occured after 60 da exposure. The MFTD was deemed to be exceeded at 64 mg/cubic meter and 16 mg/cubic meter was chosen for the chronic study high concentration. (ITA)