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Spontaneous neoplastic lesions in Harlan Sprague-Dawley rats

: Kaspareit, J.; Rittinghausen, S.

Experimental and Toxicologic Pathology 51 (1999), Nr.1, S.105-107
ISSN: 0940-2993
Fraunhofer ITA ( ITEM) ()
adenoma; Pituitary gland; rat; Tumors

In a 24-months study, the spontaneous tumour spectrum of the Hsd:Sprague-Dawley stock was examined. Pituitary gland tumours were found in 20 per cent of the males and 39 per cent of the females. This relatively low incidence, compared to other SPRD stocks, had little effect on the survival of the females (50 per cent), due to the high incidence (76 per cent) of mammary gland tumours (predominantly fibroadenomas) resulted in unscheduled sacrifices of many female. Other common neoplasms in Hsd:Sprague-Dawley rats were benign medullary tumours (27 per cent in males, 11 per cent in females), C-cell adenomas (23 per cent in males, 28 per cent in females), and endometrial stromal polyps (22 per cent in females).