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A silicon based microsystem for continuous in vivo glucose monitoring using a new reversible measuring principle

: Knoll, D.; Ehwald, K.-E.; Ehwald, R.; Sorge, R.; Ballerstädt, R.; Bollerott, M.

Krahn, R.; Reichl, H. ; Ausstellungs-, Messe-, Kongreß-GmbH -AMK-, Berlin:
Micro System Technologies '91
Berlin: VDE-Verlag, 1991
ISBN: 3-8007-1819-7
International Conference on Micro Electro, Opto, Mechanic Systems and Components <2, 1991, Berlin>
Fraunhofer IMS ()
14C labeled ß-active lectin molecules; diffusion chamber; glucose monitoring; integrated radioactive affinity sensor; long-term stability; sensor microsystem

In this paper the concept of an integrated silicon based radioactive sensor microsystem is presented. The sensor is designed for long term measurement of blood glucose concentration of diabetic patients. The sensor itself is implanted. It is controlled and read out by a small external part which contains mergy source, the signal processing circuit and a display unit. The sensor itself is a detector for electron radiation and it is able to measure the ß-activity of 14C labeled lectin molecules. The amount of the lectin molecules in the two measuring chambers changes in one proportional chamber and reversible with changing glucose concentration.