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Reversibility of clearance impairment after subchronic test toner inhalation

: Kilpper, R.; Bellmann, B.; Creutzenberg, O.; Mermelstein, R.; Morrow, P.E.; Muhle, H.

Experimental Pathology 37 (1989), Nr.1-4, S.234-238
ISSN: 0232-1513
Fraunhofer ITA ( ITEM) ()
alveolar clearance; burden; clearance impairment; Inhalation; inhalation experiment; lung; lymph node; particle transfer; pulmonary burden; test toner; test toner Inhalation

In a chronic study of a test toner in F-344 rats an impairment of alveolar clearance and increased toner retention were observed at the high and, to a lesser degree, at the middle exposure level throughout the study. The objectives of the present study were: 1. To investigate the nature and the timer course of test toner and surrogate tracer alveolar clearance and toner retention behaviour following a subchronic exposure interval. 2. To investigate the dependence of the response upon the pulmonary burden of the test toner.