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Absence of effect of caffeine on the thyroid in the syrian golden hamster

Results of a 90-day study
: Bartsch, W.; Dasenbrock, C.; Ernst, H.; Kamino, K.; Mohr, U.


Food and Chemical Toxicology : FCT 34 (1996), Nr.2, S.153-159
ISSN: 0278-6915
ISSN: 1873-6351
Fraunhofer ITA ( ITEM) ()
caffeine; golden hamster; pathology; thyroid gland; thyroid hormone

Caffeine in drinking water was offered ad lib. to male and female Syrian golden hamsters (Mesocricetus auratus W) for 90 days. Animals were randomly assigned to three dose groups (91.3,274 and 822 mg/litre) and one control group (filtered tap water), each consisting of 20 male and 20 female animals. In relation to body weight, mean caffeine consumption was higher in females (low dose: 14.7; medium dose: 50.8; high dose: 104.8 mg/kg body weight/day) than males (low dose: 9.0; medium dose: 24.6; high dose: 65.2 mg/kg body weight/day). Caffeine in plasma was measured after 3 days, 3wk and 3 months of treatment. As expected from calculation of the caffeine intake, mean values were higher in females (low dose: 0.6; medium dose: 3.6; high dose 7.2 mg/litre) than in males (low dose: 0.4; medium dose: 0.7; high dose: 2.9 mg/litre). After 3 days of treatment, a transient, non-dose-related increase in mean (SEM)tri-iodothyronine (n=10) was found in the medium and high dose. (Abstract truncated)