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Phagocytosis and chemotaxis of rat alveolar macrophages after a combined or separate exposure to ozone and carbon black


Medizinische Hochschule Hannover; International Life Sciences Institute -ILSI-, Washington/D.C.; Fraunhofer-Institut für Toxikologie und Aerosolforschung -ITA-, Hannover:
Toxic and carcinogenic effects of solid particles in the respiratory tract. Abstracts : 4th International Inhalation Symposium, Hannover
Hannover, 1993
International Inhalation Symposium <4, 1993, Hannover>
International Symposium on Inhalation Toxicology <4, 1993, Hannover>
Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract <1993, Hannover>
Fraunhofer ITA ( ITEM) ()
carbon-black; chemotaxis; diesel soot; inhalation toxicology; intratracheal instillation; lung; macrophage; ozone; phagocytosis; pulmonary alveoli; pulmonary surfactant; rat; surface active agent; toxicity testing; toxicology

A combined exposure to ozone and diesel soot may induce more severe health effects than an exposure to the single components. In this study, rats were treated by ozone or carbon black (CB) alone as well as in a combination. Male Wistar rats were exposed in the following 6 groups: clean air, 0,5 ppm ozone, 0,15 mg CB, 0,5 mg CB, 0,5 mg CB/0,5 ppm ozone and 1,5 mg CB/0,5 ppm ozone. After the intratracheal administration of CB, animals inhaled ozone for 2 months, 6h/day, 5 days/week. The effects on the lung were investigated including measurements of lung mechanics, surfactant, histopathology and cellular and soluble parameters of the bronchoalveolar lavagate. From these investigations only the results of two methods will be presented in this paper, i.e. the phagocytosis and the chemotactic migration capability of alveolar macrophages. (Abstract truncated)