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Orally administered cyclosporine-A improves red blood cell velocity in capillaries of conscious SD-rats

: Bossaller, C.; Hertel, R.F.

International journal of microcirculation, Clinical and experimental 8 (1989), Nr.1, S.98
ISSN: 0167-6865
Gesellschaft für Mikrozirkulation (Jahrestagung) <12, 1988, Bern>
Fraunhofer ITA ( ITEM) ()
blood vessel; Blutgefäß; capillary vessel; cyclosporine-A; DS-rat; Kapillare; Kapillargefäß; microcirculation; Mikrozirkulation; rat; Ratte; SD-Ratte

The aim of this study was to investigate red blood cell velocity (Very; flying spot technique) and diameters of capillaries (Ocap, angiometer or ruler) of conscious rats after orally administered Cyclosporine-A (CyA). From other experiments (aortic ring preparations) with our rats we know that alpha1-adrenergic vasoconstriction is enhanced and endothelium-dependent as well as endothelium-independent vascular relaxation are depressed; thus we conclude, that the increase of Very after CyA treatment reflects an enhanced vascular tone in the precapillary arterial system.