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Odontogenic fibroma in Sprague-Dawley rats: a report of 2 cases

: Ernst, H.; Scampini, G.; Durchfeld-Meyer, B.; Brander-Weber, P.; Rittinghausen, S.

Experimental and Toxicologic Pathology 50 (1998), Nr.4-6, S.384-388
ISSN: 0940-2993
Fraunhofer ITA ( ITEM) ()
Fibromas; Odontogenic tumors; rat

Two cases of odontogenic fibroma occuring in aged Sprague-Dawley rats are described. Both neoplasms were associated with maximillary incisor and had identical histomorphological features. They were composed of solid proliferations of primitive, dental pulp-like mesenchym seperated by areas of collagenization. Small strands and islands of mainly undifferentiated odontogenic epithelium immunostaining for keratins were scattered troughout both tumours. As a further characteristic, the lesions contained small foci of mineralization which were either cementum-like or resembled dysplastic dentin. The odontogenic fibroma represents a further type of odontogenic tumour in rats, which due to its typical histomorphology, can easily be differentiated from other odontogenic tumours such as ameloblastic odontoma or ameloblastoma.