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1994
Journal Article
Titel
Nasal retention and clearance of wood dust in rats
Abstract
The objective of this study was to develop an animal model in which the nasal cavities can be tested as a target organ for wood dust. The intranasal instillation and the inhalation route were investigated as alternative treatment methods. A wood dust fraction with a mass median aerodynamic diameter of 4-5um was used which was labelled by the 51Cr tracer technique. An apparent deposition fraction of about 25% was determined by inhalation. The clearance halftimes were 200-250 min for both administration methods. However, the standard deviation was higher after intranasal installation. The reproducibility of dosing improved after inhalation exposure which leads to a more even distribution of particles in the nasal cavities. Histopathological investigations showed inflammatory processes after repeated intranasal instillation. (Abstract truncated)
Language
English