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Inhalation experiments on retention and lung clearance of asbestos in combination with cigarette-smoking

: Bellmann, B.; Muhle, H.; Pott, F.; Spurny, K.R.

Wehner, A.P.; Felton, D.-L.:
Biological interaction of inhaled mineral fibers and cigarette smoke. Proceedings of an International Symposium/Workshop
Columbus, Ohio: Batelle Press, 1989
ISBN: 0-935470-44-1
International Symposium/Workshop Interaction Biological Fibers <1988, Seattle/Wash.>
Fraunhofer IUCT ( IME) ()
asbestos; cigarette smoking; crocidolite; exposure; fibre; Inhalation; lung clearance; pulmonary retention; rat

Rats received nose-only exposure to 11,4 mg/m3 UICC crocidolite and 2,5mg/m3 UICC chrysotile A for 2 hours a week for a period of up to 1 year. One-half of the animals also inhaled cigarette smoke, diluted 1:5 with filtered air, twice daily for 34 minutes at a time, 5 days a week. Long-term lung clearance of a radioactively labeled aerosol was determined after 2 and 9 months of exposure. Cigarette smoking decreased lung clearance of inhaled labeled particles. After 2,6 and 12 months of exposure the animals were sacrificed, and organs were ashed in a low-temperature ashing furnace. The number of fibers, and their length and diameter distribution, were examined in both tissue samples and in samples of exposure chamber air, using a scanning electron microscope. Results showed a factor-of-two increase of crocidolite fibers in the lungs of groups also exposed to cigarette smoke, compared to the animals that did not inhale cigarette smoke. No such effect of cigarette-smoking was found on chr ysotile fiber retention. The difference between these results may be due to the different deposition patterns of the two fiber types.