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Inhalation and injection experiments in rats for testing carcinogenicity of MMMF

: Ziem, U.; Bellmann, B.; Muhle, H.; Pott, F.; Takenaka, S.

International Symposium Man-Made Mineral Fibres in the Working Environment
Man-Made Mineral Fibres in the Working Environment <1986, Copenhagen>
Fraunhofer ITA ( ITEM) ()
asbestos; carcinogenicity; glass fibre; Inhalation; rat

Parallel inhalation and intraperitoneal injection (i.p.) experiments with rats, the glass fibre JM 104, Tempstran 475, was used as a prototype of very thin and durable man-made mineral fibres (MMMF). This fibre was compared to crocidolite (South Africa) and chrysotile (California, Calidria RG 144). Aerosol concentrations were 2.2 to 6 mg/cubic meter. Exposure lasted one year. No significant tumour rate was found in the inhalation test. After crocidolite exposure in 74% of the animals bronchiolo-alveolar hyperplasia was detected. An exposure combination of 100 ppm SO sub 2 and glass fibres did not induce a statistically significant tumour rate either. Intraperitoneal injection of 0.5 mg of the three different fibre types showed a tumour rate of 17% for glass fibre JM 104, 55% for crocidolite and only 6% for Calidria chrysotile. Calidria chrysotile seems to be much less persistent than other chrysotile samples.