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An experimental animal study for risk assessment of indoor air pollutants.

Tierexperimentelle Untersuchung zur Risikoanalyse von Innenraum-Luftschadstoffen
: Glaser, U.; Hochrainer, D.; Klein, W.; Otto, F.

Environment international 15 (1989), S.463-472 : Abb.,Tab.,Lit.
ISSN: 0160-4120
Fraunhofer IUCT ( IME) ()
Anorganisches und Organisches Gas; indoor air pollutant; Inhalation; Innenraumluftschadstoff; inorganic and organic gas; rat

Male Wistar rats were exposed in horizontal-flow inhalation chambers to low concentrations of gaseous and particulate indoor air pollutants for one month. A second series of rats was exposed in the same way and observed for an additional two months. The study was performed with the following groups: (1) Continuous basic exposure to NO2 (0.1 mL/cbm), CO (20 mL/cbm), and CO2 (2 L/cbm), and respirable textile particles (0.2 mg/cbm); (2) Additional exposure to a mixture of 20 volatile organics (solvent group: 0.2 mg/cbm; smaller than 1/10 of the TLV for each chemical); (3); Additional exposure to vapors from frying fish in fat (kitchen vapors: 20 mg/cbm) for one hour twice a day. After the inhalation period, several subclinical effects found in experimental rats compared to control rats breathing filtered fresh air. There were hematological changes due to carbon monoxide as well as clinico-biochemical effects and immune modulation due to exposure to the solvent mixture and kitchen vapors. Most significant effects were seen in the lung-cell DNA mesured by flow cytometry. Indications for genotoxicity for all exposed groups were not reversed after two months of observation in flitered fresh air.