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Effects of chronic Cyclosporine-A treatment on the skin microcirculation of conscious rats.

Untersuchungen an der Mikrozirkulation der Haut nach chronischer Behandlung mit Cyclosporin A
: Bossaller, C.; Hertel, R.F.

Zeitschrift für Kardiologie 78 (1989), Nr.6, S.92-94
ISSN: 0300-5860
Fraunhofer ITA ( ITEM) ()
Cyclosporin A; cyclosporine A; Haut; Mikrozirkulation; rat; Ratte; skin

We investigated capillary diameter and red blood cell velocity in the skin of conscious rats treated for eight weeks with oral doses of Caclosporine A or placebo. For the intavital microscopic analysis, the depilated auricle was used as a model. The capillary diameter did not differ between CyA and controls. However, the red blood cell velocity was significantly different. Additional experiments of our group with isolated arteries revealed an impaired response endothelium-dependent and -independent vasodilators in the presence of an enhanced response to alpha adrenergic vasoconstriction in the CyA treated rats. Thus, the increase of capillary red blood cell velocity in chronically CyA treated rats may reflect an enhanced vascular tone of the precapillary circulation.