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Dust overloading of lungs after exposure of rats to particles of low solubility. Comparative studies


Journal of Aerosol Science 21 (1990), Nr.3, S.374-377
ISSN: 0021-8502
Fraunhofer ITA ( ITEM) ()
aerosol; alveolar clearance; carbon black; dust; inhalation study; lung; polyvinyl chloride; rat; titanium; titanium dioxide; toner

Rats were exposed to dusts of polymers, carbon black and two types of titanium dioxide. In these subchronic and chronic studies the characteristic findings were a disproportional accumulation of the insoluble materials in lungs at high exposure concentrations, impairment of the alveolar clearance and an inflammatory response.