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Modelling and Simulation of Biotechnological Processes: BIOSIM-A Package suitable for Integration in Process Engineering Tools

: Bergstedt, U.; Körner, H.-J.; Kabasci, S.; Deerberg, G.

Pierucci, S. ; Associazione Italiana di Ingegneria Chimica -AIDIC-; European Federation of Chemical Engineering -EFCE-:
European Symposium on Computer Aided Process Engineering 2000. ESCAPE-10 : 7 - 10 May, 2000, Florence, Italy. 33. European Symposium of the Working Party on Computer Aided Process Engineering, 619. Event of the European Federation of Chemical Engineering (EFCE)
Amsterdam: Elsevier, 2000 (Computer-aided chemical engineering 8)
ISBN: 0-444-50520-2
ISBN: 978-0-444-50520-0
European Symposium on Computer Aided Process Engineering (ESCAPE) <10, 2000, Firenze>
Fraunhofer UMSICHT Oberhausen ()
bioreaction; modeling; simulation; optimization; fermentation process; Modellierung; Fermentationsprozeß; Optimierung; Bioreaktion

A bioreactor can be described as a heterogeneous system with at least three structural phases: the liquid, the gas, which together form the abiotic phase and the biological phase, which consists of the cell population. Our model is based on the zone cell network model for the stirred tank reactor containing two physical phases. The models for process engineering and biological processes are formulated separately and implemented in a suitable program structure. The progam enables to calculate different combinations of biological models and submodels in a process technology context.