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Graft rejection: Pharmacogenetic analysis or drug anamnesis

: Pham, V.V.; Stichtenoth, D.O.; Borlak, J.


British journal of clinical pharmacology 65 (2008), Nr.6, S.959-960
ISSN: 0306-5251
ISSN: 0264-3774
Fraunhofer ITEM ()
tacrolimus; sirolimus; Cytochrome P-450; polymorphism; CYP 3A

AIMS: A 23-year-old Caucasian woman, with cystic fibrosis, bilateral lung-transplantation and immunosuppressive therapy with prednisolone, tacrolimus and sirolimus, presented with clinical symptoms of a chronic transplant rejection. METHODS: Since constant sufficient blood level of tacrolimus and sirolimus had never been achieved, a genetic analysis was carried out to clarify drug metabolism. RESULTS: The genetic analysis for polymorphisms of cytochrome P450 (CYP) 3A4,5,7 revealed no sequence alterations in the CYP 3A4,5,7 gene. Thus, drug intake was scrutinized in detail, disclosing a missing interval between the intake of both immunosuppressive agents. After a correct drug intake the woman's condition ameliorated and the blood levels reached normal range. CONCLUSIONS: This case report highlights the crucial importance of basic medical skills like an accurate and dainty drug anamnesis before high tech approaches were applied.