Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Self-assembling flexible 3D-MEAs for cortical implants

: Hegel, Lena; Kauth, Andrea; Seidl, Karsten; Ingebrandt, Sven

Volltext ()

Current directions in biomedical engineering 7 (2021), Nr.2, S.359-363
ISSN: 2364-5504
Deutsche Gesellschaft für Biomedizinische Technik (DGBMT Jahrestagung) <55, 2021, Hannover>
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer IMS ()
flexible MEAs; polyimide; polycondensation shrinkage; self-assembling electrodes

Flexible Multi Electrode Arrays (MEAs) for neural interfacing reduce the mechanical mismatch between the soft brain tissue and the electrode arrays allowing accurate signal recordings and neural stimulation while reducing inflammatory responses. Many standard manufacturing processes of MEAs are designed for planar structures and the production of three-dimensional structures is challenging. In the present study, shaft structures with one to two circular gold microelectrodes (10 - 20 μm), each on a base polyimide (PI) substrate, were investigated. We describe a fabrication method, with which shafts made from bi-layer PI flip into the third dimension, which is a first step towards spontaneous assembly of electrodes in flexible 3D MEAs for neuroelectronic applications. A lift-up of the shafts was achieved by the contraction of a second PI layer and a steady nitrogen flow during polycondensation. This shrinking PI was structured in pits with a width of 5 - 600 μm. We achieved liftup angles of up to 42 degrees. The shaft structures can be hardened and later be used for neural implantation experiments.