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Mechanically stable β-TCP structural hybrid scaffolds for potential bone replacement

: Ahlhelm, Matthias; Laterro, Sergio H.; Mayr, Hermann O.; Storch, Christiane; Freytag, Christian; Werner, David; Schwarzer-Fischer, Eric; Seidenstücker, Michael

Volltext ()

Journal of composites science 5 (2021), Nr.10, Art. 281, 26 S.
ISSN: 2504-477X
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer IKTS ()
Fraunhofer IZI ()
Freeze Foam; hybrid bone; biocompatibility; bone replacement

The authors report on the manufacturing of mechanically stable β-tricalcium phosphate (β-TCP) structural hybrid scaffolds via the combination of additive manufacturing (CerAM VPP) and Freeze Foaming for engineering a potential bone replacement. In the first step, load bearing support structures were designed via FE simulation and 3D printed by CerAM VPP. In the second step, structures were foamed-in with a porous and degradable calcium phosphate (CaP) ceramic that mimics porous spongiosa. For this purpose, Fraunhofer IKTS used a process known as Freeze Foaming, which allows the foaming of any powdery material and the foaming-in into near-net-shape structures. Using a joint heat treatment, both structural components fused to form a structural hybrid. This bone construct had a 25-fold increased compressive strength compared to the pure CaP Freeze Foam and excellent biocompatibility with human osteoblastic MG-63 cells when compared to a bone grafting Curasan material for benchmark.