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Haemocompatibility testing allows selective adaption of GA-free SULEEI-preparation strategy for bovine pericardium

: Dittfeld, C.; König, Ulla; Welzel, C.; Jannasch, A.; Matschke, K.; Sperling, C.; Tugtekin, S.-M.; Maitz, M.


European Heart Journal 42 (2021), Supplement 1, Artikel ehab724.3336, 1 S.
ISSN: 0195-668X
ISSN: 1522-9645
European Society of Cardiology (ESC Congress) <2021, Online>
Fraunhofer FEP ()
Heart Disease; blood cells; pericardial sac; radiation

Bovine pericardium is the main natural source for patches or valve substitutes in cardiac surgery, but still, long-term durability is limited. An alternative, glutaraldehyde (GA)-free preparation combining decellularization, riboflavin/UVA crosslinking, and low-energy electron irradiation (SULEEI) procedure was established to avoid this. Protocol optimization is ongoing to further improve the final material. Haemocompatibility in vitro testing with fresh, human whole blood has advantages for material analysis, as it provides essential information on the activation of the complement system and immune cells therefore substantiating and possibly reducing the amount of animal testing.