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Three new andrastin derivatives from the endophytic fungus Penicillium vulpinum

 
: Qin, Y.-Y.; Huang, X.-S.; Liu, X.-B.; Mo, T.-X.; Xu, Z.-L.; Li, B.-C.; Qin, X.-Y.; Li, J.; Schäberle, T.F.; Yang, R.-Y.

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Natural product research (2020), Online First
ISSN: 1478-6419
ISSN: 1478-6427
Englisch
Zeitschriftenaufsatz
Fraunhofer IME ()

Abstract
Three new andrastin derivatives, 10-formyl andrastone A (1), 10-demethylated andrastone A (2) and andrastin G (3), together with four known andrastin analogues (4-7) were isolated from an endophytic fungus Penicillium vulpinum. Their structures were determined by 1 D, 2 D NMR, and the absolute configurations were further determined by experimental and calculated ECD spectra. Compound 5 exhibited significant antibacterial activity against Bacillus paratyphosus B with an MIC value of 6.25 µg·mL−1. Compounds 2 and 6 showed remarkable inhibitory activities against Bacillus megaterium with the MIC value of 6.25 µg·mL−1, respectively.

: http://publica.fraunhofer.de/dokumente/N-639821.html