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A dithiacyclam-coordinated silver(I) polymer with anti-cancer stem cell activity

: Johnson, A.; Iffland, L.; Singh, K.; Apfel, U.-P.; Suntharalingam, K.

Volltext ()

Dalton transactions 50 (2021), Nr.17, S.5779-5783
ISSN: 1477-9226
ISSN: 2209-2386
ISSN: 1477-9234
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer UMSICHT Oberhausen ()

A cancer stem cell (CSC) active, solution stable, silver(i) polymeric complex bearing a dithiacyclam ligand is reported. The complex displays similar potency towards CSCs to salinomycin in monolayer and three-dimensional cultures. Mechanistic studies suggest CSC death results from cytosol entry, an increase in intracellular reactive oxygen species, and caspase-dependent apoptosis.