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T1a Glottic Cancer: Advances in Vocal Outcome Assessment after Transoral CO2-Laser Microsurgery Using the VEM

 
: Song, Wen; Caffier, Felix; Nawka, Tadeus; Ermakova, Tatiana; Martin, Alexios; Mürbe, Dirk; Caffier, Philipp P.

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Volltext urn:nbn:de:0011-n-6364159 (1.3 MByte PDF)
MD5 Fingerprint: 6ed28c08a101bf00a656ae28d9f6d0ab
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Erstellt am: 3.7.2021


Journal of Clinical Medicine 10 (2021), Nr.6, Art. 1250, 17 S.
ISSN: 2077-0383
Englisch
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer FOKUS ()
T1a glottic carcinoma; transoral laser microsurgery; treatment outcome; vocal function; objective voice diagnostics; vocal extent measure (VEM)

Abstract
Patients with unilateral vocal fold cancer (T1a) have a favorable prognosis. In addition to the oncological results of CO2 transoral laser microsurgery (TOLMS), voice function is among the outcome measures. Previous early glottic cancer studies have reported voice function in patients grouped into combined T stages (Tis, T1, T2) and merged cordectomy types (lesser- vs. larger-extent cordectomies). Some authors have questioned the value of objective vocal parameters. Therefore, the purpose of this exploratory prospective study was to investigate TOLMS-associated oncological and vocal outcomes in 60 T1a patients, applying the ELS protocols for cordectomy classification and voice assessment. Pre- and postoperative voice function analysis included: Vocal Extent Measure (VEM), Dysphonia Severity Index (DSI), auditory-perceptual assessment (GRB), and 9-item Voice Handicap Index (VHI-9i). Altogether, 51 subjects (43 male, eight female, mean age 65 years) completed the study. The 5-year recurrence-free, overall, and disease-specific survival rates (Kaplan–Meier method) were 71.4%, 94.4%, and 100.0%. Voice function was preserved; the objective parameter VEM (64 ± 33 vs. 83 ± 31; mean ± SD) and subjective vocal measures (G: 1.9 ± 0.7 vs. 1.3 ± 0.7; VHI-9i: 18 ± 8 vs. 9 ± 9) even improved significantly (p < 0.001). The VEM best reflected self-perceived voice impairment. It represents a sensitive measure of voice function for quantification of vocal performance.

: http://publica.fraunhofer.de/dokumente/N-636415.html