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Endogenous retroviruses in nervous system disorders

: Gröger, Victoria; Emmer, Alexander; Staege, Martin Sebastian; Cynis, Holger

Volltext ()

Pharmaceuticals 14 (2021), Nr.1, Art. 70, 19 S.
ISSN: 1424-8247
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer IZI ()
human endogenous retrovirus; multiple sklerosis; amyotrophic lateral sclerosis; monoklonaler Antikörper

Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pathogenesis of currently incurable diseases might offer new treatment strategies based on the inhibition of HERV activities by small molecules or therapeutic antibodies.