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Inhalation studies with the Göttingen minipig

: Koch, W.; Windt, H.; Walles, M.; Borlak, J.; Clausing, P.


Inhalation Toxicology 13 (2001), Nr.3, S.249-259
ISSN: 0895-8378
ISSN: 1091-7691
Fraunhofer ITA ( ITEM) ()
inhalation toxicology; chemical; drug; gas; Pharmacokinetic; medicine experiment

A method for inhalative exposure of minipigs to aerosols and gases has been developed. Minipigs are exposed via mask inhalation to the test substance using a computer-controlled exposure system that permits simultaneous exposure of groups of four animals in parallel to different controlled dose levels. We studied inhalation treatment of verapamil, a cardiovascular drug, and show good absorption and favorable pharmacokinetics when compared with in drug application. The results shown in this study encourage inhalation studies with the Göttingen minipig.