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Neurophotonic scanning system - towards automatic infrared neurostimulation

: Wegner, Celine; Schlett, Paul; Hofmann, Ulrich G.; Höth, Julian; Klotzbücher, Thomas; Buckert, Thomas; Krüger, Thilo B.

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Current directions in biomedical engineering 6 (2020), Nr.3, Art. 20203069, 4 S.
ISSN: 2364-5504
Bundesministerium für Bildung und Forschung BMBF (Deutschland)
13GW0155A; NeuroPhos
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer IMM ()
Intraoperative Neuromonitoring; Surgical Mapping; Neurostimulation; Infrared Optical Stimulation; laser stimulation

Intraoperative neuromonitoring is without doubt important for all surgical interventions, where nerve structures are at risk. Mapping techniques for the identification of motor nerves and cortex are available. They rely on manual identification using an electrical stimulation probe. A landmark-based visualization of the results is currently not possible. To overcome these limitations, we are developing a system for automatic stimulation and display of functional tissue.
Infrared neurostimulation (INS) was proposed to be a feasible alternative to electrical stimulation of nerves. It provides contactless and artifact-free activation of nerves. For our preclinical experiments we used an infrared diode laser system with a wavelength of 1470 nm. For automatic screening, we developed a scanning system and suitable scan-algorithms in order to provide optimal scanning parameters. Recording of compound muscle action potentials (CMAP) was performed with a differential amplifier and appropriate neurophysiologic software.
Subunits of the system were combined via multiple interfaces. A control-software merges all relevant functions of the individual parts and parallel use. Marking of tissue was realized with a red pilot laser deflected by the same scanning system.
With this work we could show, that a system for automatic laser deflection with parallel neurophysiologic recording and subsequent highlighting of irradiated tissue is possible. This system can serve as a tool for further systematic investigations in the field of INS.