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Tracking the chiral recognition of adsorbed dipeptides at the single-molecule level

: Lingenfelder, M.; Tomba, G.; Costantini, G.; Colombi Ciacchi, L.; Vita, A. de; Kern, K.


Angewandte Chemie. International edition 46 (2007), Nr.24, S.4492-4495
ISSN: 1433-7851
ISSN: 0044-8249
ISSN: 0570-0833
ISSN: 1521-3773
Fraunhofer IWM ()
single-molecule level; molecular recognition

Specific molecular recognition depends on the precisely defined arrangement of atoms in complementary structures interacting by short-range forces. The mutual interactions between complementary molecules can result in their recognition even if their static molecular structure is not optimized for specific binding. This mechanism of dynamic induced fit, orginally introduced by Pauling in 1948 and developed by Koshland for enzymatic activity, is today the generally accepted picture in biomolecular recognition processes.