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Effects of gut microbial metabolite trimethylamine N-oxide (TMAO) on platelets and endothelial cells

: Krüger-Genge, Anne; Jung, Friedrich; Hufert, Frank; Jung, Ernst Michael; Küpper, Jan-Heiner; Storsberg, Joachim


Clinical hemorheology and microcirculation 76 (2020), Nr.2, S.309-316
ISSN: 1386-0291
ISSN: 1875-8622
Fraunhofer IAP ()

Thrombotic events result from different pathologies and are the underlying causes of severe diseases like stroke or myocardial infarction. Recent basic research now revealed a link between food uptake, food conversion and gut metabolism. Gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin and L-carnitine was associated with the development of cardiovascular diseases. Within this review we give a systematic overview about the influence of TMAO on blood components like platelets and endothelial cells which both are involved as key players in thrombotic processes. In summary, a mechanistic correlation between the gut microbiome, TMAO and cardiovascular diseases becomes obvious and emphasizes to the significance of the intestinal microbiome.