Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Mechanisms of Interactions between Bile Acids and Plant Compounds - A Review

 
: Naumann, Susanne; Haller, Dirk; Eisner, Peter; Schweiggert-Weisz, Ute

:
Volltext ()

International journal of molecular sciences 21 (2020), Nr.18, Art. 6495, 20 S.
ISSN: 1422-0067
ISSN: 1661-6596
Englisch
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer IVV ()

Abstract
Plant compounds are described to interact with bile acids during small intestinal digestion. This review will summarise mechanisms of interaction between bile acids and plant compounds, challenges in in vivo and in vitro analyses, and possible consequences on health. The main mechanisms of interaction assume that increased viscosity during digestion results in reduced micellar mobility of bile acids, or that bile acids and plant compounds are associated or complexed at the molecular level. Increasing viscosity during digestion due to specific dietary fibres is considered a central reason for bile acid retention. Furthermore, hydrophobic interactions are proposed to contribute to bile acid retention in the small intestine. Although frequently hypothesised, no mechanism of permanent binding of bile acids by dietary fibres or indigestible protein fractions has yet been demonstrated. Otherwise, various polyphenolic structures were recently associated with reduced micellar solubility and modification of steroid and bile acid excretion but underlying molecular mechanisms of interaction are not yet fully understood. Therefore, future research activities need to consider the complex composition and cell-wall structures as influenced by processing when investigating bile acid interactions. Furthermore, influences of bile acid interactions on gut microbiota need to be addressed to clarify their role in bile acid metabolism.

: http://publica.fraunhofer.de/dokumente/N-602298.html