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Kinetics of threading alpha-cyclodextrin onto cationic and zwitterionic poly(bola-amphiphiles)

: Wenz, G.; Gruber, C.; Keller, B.; Schilli, C.; Albuzat, T.; Müller, A.


Macromolecules 39 (2006), Nr.23, S.8021-8026
ISSN: 0024-9297
ISSN: 1520-5835
Fraunhofer IGB ()

The amphiphilic polymers, poly(iminoundecamethylene), poly((N-methylimino)undecamethylene), poly((N,N-dimethylammonio)undecamethylene), and poly((N-methylimino)undecamethylene-N-oxide) were synthesized from nylon-11 by BH3 reduction of amide groups to amino groups and subsequent methylations. The poly(N-oxide) was obtained by H2O2 oxidation of the polymeric tertiary amine. Since the polymers and their inclusion compounds were water-soluble, threading kinetics of alpha-cyclodextrin rings onto these polymers could be investigated by H-1 NMR. Kinetics were fitted by an empirical root exponential association function Y = Y-infinity(1 -exp(-sqrt(5.3t/t(90)))). The time t(90), necessary to reach 90% completion of the threading process, was taken as a measure of the steric hindrance exerted by the hydrophilic groups along the polymer chain. The values of t(90) decreased by more than 3 orders of magnitude as the diameters of the hydrophilic groups decreased from 5.5 to 4.3 angstrom.