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2020
Poster
Titel
Rapid development of micro-physiological systems using novel modular plug&play construction kit
Titel Supplements
Poster presented at Annual EUROoCS Conference 2020, 8.-9.7.2020, online (previously scheduled Uppsala)
Abstract
Micro-physiological platforms (MPS) - often referred as organ-on-chip or multi-organ-chip - have an enormous potential to strengthen research in drug development, toxicological screening, personalized medicine and disease modeling. The design of such MPS is an interdisciplinary challenge. At the beginning of development, many parameters and boundary conditions (geometries, volumes, flow rates, interfaces, and coatings) are often still unknown. The probability that the first draft will work is therefore very low. A large number of design cycles are necessary to develop a miniaturized MPS with a high functional density. However, we designed a modular plug&play construction kit for the development of MPS. The modular system provides a large number of functional, miniaturized modules such as pumps, oxygenators, reservoirs, sensors and cell culture compartments whose fluidic interfaces comply with the Luer-Lock standard. This allows a quick and easy combination of modules with each other, according to the intended application. By using the modular plug&play construction kit, the successful creation of different MPS setups has achieved in the shortest time and with minimal effort. A quick and easy integration of microfluidic components, pumps and sensors from third party suppliers is possible. Thus, with the help of the modular plug&play construction kit, a drastically reduction of financial and time expenditure of an MPS development is possible. Once an application-specific design has been successfully determined, it is possible to derive a compact MPS by following certain design rules.