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Photopatternable, Branched Polymer Hydrogels Based on Linear Macromonomers for 3D Cell Culture Applications

 
: Tong, Ciqing; Wondergem, Joeri A.J.; Kieltyka, Roxanne E.

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Volltext ()

ACS Macro Letters 9 (2020), Nr.6, S.882-888
ISSN: 2161-1653
Englisch
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer ISC ()
Disulfides; nucleic acid structure; hydrogels; polymers; irradiation

Abstract
Photochemical ligation strategies in hydrogel materials are crucial to model spatiotemporal phenomena that occur in the natural extracellular matrix. We here describe the use of cyclic 1,2-dithiolanes to cross-link with norbornene on linear poly(ethylene glycol) polymers through UV irradiation in a rapid and byproduct-free manner, resulting in branched macromolecular architectures and hydrogel materials from low-viscosity precursor solutions. Oscillatory rheology and NMR data indicate the one-pot formation of thioether and disulfide cross-links. Spatial and temporal control of the hydrogel mechanical properties and functionality was demonstrated by oscillatory rheology and confocal microscopy. A cytocompatible response of NIH 3T3 fibroblasts was observed within these materials, providing a foothold for further exploration of this photoactive cross-linking moiety in the biomedical field.

: http://publica.fraunhofer.de/dokumente/N-593525.html