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Realizing flexible bioelectronic medicines for accessing the peripheral nerves - technology considerations

: Giagka, Vasiliki; Serdijn, Wouter A.

Volltext ()

Bioelectronic medicine 4 (2018), Art. 8, 10 S.
ISSN: 2332-8886
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer IZM ()

Patients suffering from conditions such as paralysis, diabetes or rheumatoid arthritis could in the future be treated in a personalised manner using bioelectronic medicines (BEms) (Nat Rev Drug Discov 13:399–400, 2013, Proc Natl Acad Sci USA 113:8284–9, 2016, J Intern Med 282:37–45, 2017). To deliver this personalised therapy based on electricity, BEms need to target various sites in the human body and operate in a closed-loop manner. The specific conditions and anatomy of the targeted sites pose unique challenges in the development of BEms. With a focus on BEms based on flexible substrates for accessing small peripheral nerves, this paper discusses several system-level technology considerations related to the development of such devices. The focus is mainly on miniaturisation and long-term operation. We present an overview of common substrate and electrode materials, related processing methods, and discuss assembly, miniaturisation and long-term stability issues.