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The Differential Anti-HIV Effect of a New Humic Substance-Derived Preparation in Diverse Cells of the Immune System

: Kornilaeva, G.V.; Siniavin, A.E.; Schultz, Anke; Germann, Anja; Moog, C.; Briesen, Hagen von; Turgiev, A.S.; Karamov, E.V.

Volltext urn:nbn:de:0011-n-5617616 (222 KByte PDF)
MD5 Fingerprint: 62aa441863889372c655f6c1eccf1a1c
Erstellt am: 17.10.2019

Acta naturae 11 (2019), Nr.2, Art. 41, 9 S.
ISSN: 2075-8243
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer IBMT ()

The anti-HIV activity of a new humic substance-derived preparation has been studied in individual pools of immune cells (CD4+ T lymphocytes, macrophages, dendritic cells). Near-complete inhibition of the HIV infection (by more than 90%) was achieved by treating each of the abovementioned cell types with non-toxic concentrations of the preparation. The inhibitory effect demonstrates the possibility of preventing the depletion of a significant portion of functionally important immune cells. A comparative study of infection inhibition in individual cell pools has allowed us to reveal the differences in the preparation’s effectiveness in each of the cell populations. A R5-tropic HIV-1 infection in macrophages exhibited maximum sensitivity to the preparation: 90% and 50% inhibition of the infection were observed in the presence of concentrations as low as 1.4 and 0.35 μg/ml, respectively. A 15- and 19-fold higher concentration was required to achieve the same extent of inhibition in dendritic cells infected with the same strain. The effectiveness of the drug in CD4 + T lymphocytes is quite comparable to its effectiveness in macrophages. The drug is universally effective for both the T- and M-tropic variants of HIV-1.