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Cytokine adsorption is a promising tool in the therapy of hemophagocytic lymphohistiocytosis

 
: Frimmel, S.; Hinz, M.; Schipper, J.; Bogdanow, S.; Mitzner, S.; Koball, S.

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International journal of artificial organs (2019), Online First
ISSN: 0391-3988
Englisch
Zeitschriftenaufsatz
Fraunhofer IZI ()

Abstract
Hemophagocytic lymphohistiocytosis is a life-threatening clinical syndrome caused by severe hypercytokinemia brought on by a highly stimulated but ineffective immune response. Animal studies and case series have demonstrated that a reduction in blood cytokine levels achieved with an extracorporeal adsorption cartridge that contains blood-compatible porous polymer beads (CytoSorb®) can effectively attenuate the inflammatory response during sepsis and possibly improve outcomes. We report a case series of two patients in which three episodes of severe hemophagocytic lymphohistiocytosis triggered by infections with herpesviridae were treated successfully with cytokine adsorption. A marked decrease in interleukin-6 plasma levels and a stable or decreasing need of vasopressor therapy were the most significant results of this treatment. Importantly, treatment was safe and well-tolerated, without any adverse events.

: http://publica.fraunhofer.de/dokumente/N-558916.html