Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Cytokine adsorption is a promising tool in the therapy of hemophagocytic lymphohistiocytosis

: Frimmel, S.; Hinz, M.; Schipper, J.; Bogdanow, S.; Mitzner, S.; Koball, S.


International journal of artificial organs (2019), Online First
ISSN: 0391-3988
Fraunhofer IZI ()

Hemophagocytic lymphohistiocytosis is a life-threatening clinical syndrome caused by severe hypercytokinemia brought on by a highly stimulated but ineffective immune response. Animal studies and case series have demonstrated that a reduction in blood cytokine levels achieved with an extracorporeal adsorption cartridge that contains blood-compatible porous polymer beads (CytoSorb®) can effectively attenuate the inflammatory response during sepsis and possibly improve outcomes. We report a case series of two patients in which three episodes of severe hemophagocytic lymphohistiocytosis triggered by infections with herpesviridae were treated successfully with cytokine adsorption. A marked decrease in interleukin-6 plasma levels and a stable or decreasing need of vasopressor therapy were the most significant results of this treatment. Importantly, treatment was safe and well-tolerated, without any adverse events.