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Biomimetic cofactors and methods for their recycling

: Zachos, I.; Nowak, C.; Sieber, V.


Current opinion in chemical biology 49 (2019), S.59-66
ISSN: 1367-5931
ISSN: 1879-0402
Fraunhofer IGB ()

Nicotinamide cofactor biomimetics (NCBs) belong to a class of compounds that, as the name suggests, mimic the structures and functions of natural nicotinamide cofactors, namely nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate and their corresponding reduced forms. The first set of NCBs was discovered in the 1930s; these were initially used to study the chemical properties of this class of cofactors as well as understand nicotinamide binding of oxidoreductases. Since then, various NCBs, enzymes, and recycling systems have evolved and lately, new NCBs have been developed and used to run biocatalytic reactions.