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Development of a multi channel piezoelectric flexural plate wave BioMEMS-sensor for rapid point-of-care diagnostics

 
: Wiemann, Matthias; Walk, Christian; Greifendorf, Dieter; Weidenmüller, Jens; Jupe, Andreas; Seidl, Karsten

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Institute of Electrical and Electronics Engineers -IEEE-:
20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII, TRANSDUCERS & EUROSENSORS 2019 : 23-27 June 2019, Berlin, Germany
Piscataway, NJ: IEEE, 2019
ISBN: 978-1-5386-8104-6
ISBN: 978-1-5386-8105-3
S.1082-1085
International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers) <20, 2019, Berlin>
European Conference on Solid-State Transducers (Eurosensors) <33, 2019, Berlin>
European Commission EC
H2020; 634415; PoC-ID
Platform for ultra-sensitive Point-of-Care diagnostics for Infectious Diseases
Bundesministerium für Bildung und Forschung BMBF (Deutschland)
16FMD01K
Bundesministerium für Bildung und Forschung BMBF (Deutschland)
16FMD02
Bundesministerium für Bildung und Forschung BMBF (Deutschland)
16FMD03
Englisch
Konferenzbeitrag
Fraunhofer IMS ()
flexural plate wave (FPW); Bio-MEMS; point of care (POC); multiplexing; respiratory syncytial virus (RSV)

Abstract
The Respiratory Syncytial Virus (RSV) is responsible for a high rate of post-neonatal deaths. An early diagnosis with accurate detection and forecast of disease outcome is vital for an effective treatment. Common diagnostics for the identification of unknown pathogens require large sample volumes and are laborious. In this work, a piezoelectric flexural plate wave (FPW) Bio-MEMS sensor utilizing multi resonating membranes was developed. The detection is based on the frequency shift of each membrane due to binding of an additional mass depending on functionalization treatment. The experimental results show a resolution of up to 14 Hz/nM RSV chemokines in complex media.

: http://publica.fraunhofer.de/dokumente/N-555714.html