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Modular manufacturing platform for continuous synthesis and analysis of versatile nanomaterials

: Bomhard, Sibylle von; Schramm, Jonas; Bleul, Regina; Thiermann, Raphael; Höbel, Peter; Krtschil, Ulrich; Löb, Patrick; Maskos, Michael


Chemical Engineering and Technology 42 (2019), Nr.10, S.2085-2094
ISSN: 0930-7516
ISSN: 1521-4125
International Conference on Micro Reaction Technology (IMRET) <15, 2018, Karlsruhe>
Zeitschriftenaufsatz, Konferenzbeitrag
Fraunhofer IMM ()

Nanoparticular materials have a great potential in various fields including technical and biomedical applications; to meet the specific requirements, a good control over the particle characteristics is mandatory. Addressing this, a modular system for the automated and continuous synthesis, workup, and analysis of a broad range of nanoparticles was developed. Application examples of inorganic (silica) and organic (polymersomes, niosomes) nanoparticles demonstrate the versatility of the production platform. Modules for downstream processing via a falling‐film microreactor or tangential flow filtration are presented. The hydrodynamic size as a key parameter is acquired in real time, with an inline dynamic light scattering device. All modules are controlled and operated by a process control system.