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Towards a fully integrated lab-on-a-chip

Flexible opto‐fluidic platform for fluorescence and microarray‐based molecular diagnostics at the point of care
: Nestler, J.; Peter, H.; Bier, F.

Volltext ()

Optik & Photonik 13 (2018), Nr.1, S.28-31
ISSN: 1863-1460
ISSN: 2191-1975
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer IZI ()

The identification of pathogens in body fluids is important for proper treatment of infections with antibiotics. Besides the pure identification of the pathogen's species, however, its antibiotic profile can be crucial with regard to their resistance to certain drugs. By the use of DNA‐based microarrays, multiple of such parameters can be measured at the same time, e.g., by fluorescence imaging. Before the optical detection, however, sample preparation and labeling steps have to be performed which require the controlled transport of liquid reagents and the sample. To perform these steps at the point of care by a portable instrument, a fully‐integrated cartridge technology is presented which can perform all the required pumping and heating steps in a chip‐card‐like format, followed by fluorescence readout of the microarray.