Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Stabilization and sterilization of pericardial scaffolds by ultraviolet and low-energy electron irradiation

: Walker, Simona; Schönfelder, Jessy; Tugtekin, Sems-Malte; Wetzel, Christiane; Hacker, Michael C.; Schulz-Siegmund, Michaela


Tissue engineering. Part C, Methods 24 (2018), Nr.12, S.717-729
ISSN: 1937-3384
Fraunhofer FEP ()
sterilization; pericardium; low-energy electron irradiation; ionizing irradiation; low energy; glutaraldehyde; SULEEI

Pericardium-based tissue transplantation is a lifesaving treatment. Commercial glutaraldehyde-treated pericardial tissue exhibits cytotoxicity, which is associated with the accelerated graft failure. Replacement of glutaraldehyde has been suggested to overcome those drawbacks. In this study, we report a toxin-free method that combines tissue stabilization with a terminal sterilization. Our data indicate that the SULEEI procedure, which is part of an issued patent, may be a promising first step toward glutaraldehyde-free pericardium-based tissue transplants. Thus, our results may contribute to improving cardiovascular treatment strategies.