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Stabilization and sterilization of pericardial scaffolds by ultraviolet and low-energy electron irradiation

 
: Walker, Simona; Schönfelder, Jessy; Sems-Malte Tugtekin; Wetzel, Christiane; Hacker, Michael C.; Schulz-Siegemund, Michaela

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Tissue engineering. Part C, Methods 24 (2018), Nr.12, S.717-729
ISSN: 1937-3384
Englisch
Zeitschriftenaufsatz
Fraunhofer FEP ()
sterilization; pericardium; low-energy electron irradiation; ionizing irradiation; low energy; glutaraldehyde; SULEEI

Abstract
Pericardium-based tissue transplantation is a lifesaving treatment. Commercial glutaraldehyde-treated pericardial tissue exhibits cytotoxicity, which is associated with the accelerated graft failure. Replacement of glutaraldehyde has been suggested to overcome those drawbacks. In this study, we report a toxin-free method that combines tissue stabilization with a terminal sterilization. Our data indicate that the SULEEI procedure, which is part of an issued patent, may be a promising first step toward glutaraldehyde-free pericardium-based tissue transplants. Thus, our results may contribute to improving cardiovascular treatment strategies.

: http://publica.fraunhofer.de/dokumente/N-531282.html