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Use of Computational Functional Genomics in Drug Discovery and Repurposing for Analgesic Indications

: Lötsch, J.; Kringel, D.


Clinical Pharmacology and Therapeutics 103 (2018), Nr.6, S.975-978
ISSN: 0009-9236
ISSN: 1532-6535
Fraunhofer IME ()

The novel research area of functional genomics investigates biochemical, cellular, or physiological properties of gene products with the goal of understanding the relationship between the genome and the phenotype. These developments have made analgesic drug research a data-rich discipline mastered only by making use of parallel developments in computer science, including the establishment of knowledge bases, mining methods for big data, machine-learning, and artificial intelligence, (Table) which will be exemplarily introduced in the following.