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An international investigation into O red blood cell unit administration in hospitals

The GRoup O Utilization Patterns (GROUP) study
: Zeller, M.P.; Barty, R.; Aandahl, A.; Apelseth, T.O.; Callum, J.; Dunbar, N.M.; Elahie, A.; Garritsen, H.; Hancock, H.; Kutner, J.M.; Manukian, B.; Mizuta, S.; Okuda, M.; Pagano, M.B.; Pogłód, R.; Rushford, K.; Selleng, K.; Sørensen, C.H.; Sprogøe, U.; Staves, J.; Weiland, T.; Wendel, S.; Wood, E.M.; Watering, L. van de; Wordragen‐Vlaswinkel, M. van; Ziman, A.; Zwaginga, J.J.; Murphy, M.F.; Heddle, N.M.; Yazerm, M.H.


Transfusion 57 (2017), Nr.10, S.2329-2337
ISSN: 0041-1132
ISSN: 1537-2995
Fraunhofer IST ()

Background: Transfusion of group O blood to non‐O recipients, or transfusion of D– blood to D+ recipients, can result in shortages of group O or D– blood, respectively. This study investigated RBC utilization patterns at hospitals around the world and explored the context and policies that guide ABO blood group and D type selection practices. Study design and methods: This was a retrospective study on transfusion data from the 2013 calendar year. This study included a survey component that asked about hospital RBC selection and transfusion practices and a data collection component where participants submitted information on RBC unit disposition including blood group and D type of unit and recipient. Units administered to recipients of unknown ABO or D group were excluded. Results: Thirty‐eight hospitals in 11 countries responded to the survey, 30 of which provided specific RBC unit disposition data. Overall, 11.1% (21,235/191,397) of group O units were transfused to non‐O recipients; 22.6% (8777/38,911) of group O D– RBC units were transfused to O D+ recipients, and 43.2% (16,800/38,911) of group O D– RBC units were transfused to recipients that were not group O D–. Disposition of units and hospital transfusion policy varied within and across hospitals of different sizes, with transfusion of group O D– units to non‐group O D– patients ranging from 0% to 33%. Conclusion: A significant proportion of group O and D– RBC units were transfused to compatible, nonidentical recipients, although the frequency of this practice varied across sites.