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Development of a piezoelectric flexural plate-wave (FPW) bioMEMS-sensor for rapid point-of-care diagnostics

: Jupe, Andreas; Livshits, Pavel; Kahnert, Stefan; Figge, Martin; Mross, Stefan; Görtz, Michael; Vogt, Holger; Goehlich, Andreas


Bonča, Janez (Ed.):
Nanostructured Materials for the Detection of CBRN : Proceedings of the NATO ARW "Nanostructured Materials for the Detection of CBRN", Kiev, Ukraine, August 14-17, 2017
Dordrecht: Springer Netherland, 2018 (NATO Science for Peace and Security Series A. Chemistry and Biology)
ISBN: 978-94-024-1306-9
ISBN: 978-94-024-1303-8 (Print)
ISBN: 978-94-024-1304-5 (Online)
Workshop "Nanostructured Materials for the Detection of CBRN" <2017, Kiev>
Fraunhofer IMS ()
flexural plate wave (FPW) Bio-MEMS sensor; ultra-sensitive point-of-care diagnostics; detection of causative agent of the infection; host response in blood and nasopharyngeal aspirate

A high rate of post-neonatal deaths is due to a Respiratory Syncytial Virus (RSV). An early diagnosis with the accurate patient stratification and forecast of disease outcome is vital for an effective treatment. Common diagnostics for the identification of unknown pathogens require large sample volumes and are laborious. In this work, a novel piezoelectric FPW Bio-MEMS sensor based on the frequency shift of a resonating membrane due to binding of an additional mass was developed. The experimental results show that the sensor, a critical part of point-of-care devices, can detect with a high degree of accuracy RSV chemokines in complex media and is much faster than standard methods.