Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Discovering time-trends of the German populations exposure to contaminants by analysis of human samples of the German Environmental Specimen Bank (ESB)

: Göen, Thomas; Lermen, Dominik; Hildebrand, Jörg; Bartel-Steinbach, Martina; Weber, Till; Kolossa-Gehring, Marike

Postprint urn:nbn:de:0011-n-4972187 (586 KByte PDF)
MD5 Fingerprint: 93cf0505774ad250bc944fe2cc484996
Erstellt am: 22.6.2018

Toxicology letters 298 (2018), S.194-200
ISSN: 0378-4274
ISSN: 1879-3169
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer IBMT ()

The German Environmental Specimen Bank (ESB) is a monitoring instrument of the German Federal Ministry for the Environment, Nature Conservationand Nuclear Safety. The permanent biobank facility is run since 1981 containing environmental and human samples from Germany. All samples are collected according to standard operating procedures (SOP). An annually standardized collection of human samples at four different regional sites of the country has been established since 1997. Routine sampling is done once a year, recruiting healthy non occupationally exposed students aged 20-29 years, in an equal gender distribution. The number of participants recruited is approximately 120 students per site and year. Directly after the annual sampling process, the human samples are analyzed for selected environmental chemicals. The time-trends of lead in blood, mercury and pentachlorophenol in 24 h-urine and polychlorinated biphenyls in plasma demonstrated a decrease of exposure during the last two decades by about 40 – 90 percent. In parallel retrospective studies using cryo-archived samples revealed increasing time trends of emerging chemicals used as substitutes for regulated toxicants.
The data demonstrates the great relevance of the ESB for the health related environmental monitoring and shows the importance of human biomonitoring as a tool in information based policy making.