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Drug-induced phospholipidosis

: Anderson, N.; Borlak, J.


FEBS Letters 580 (2006), Nr.23, S.5533-5540
ISSN: 0014-5793
ISSN: 1873-3468
Fraunhofer ITEM ()
cationic amphiphilic drug; lamellar body; Lysosomes

Drug-induced phospholipidosis is characterized by intracellular accumulation of phospholipids with lamellar bodies, most likely from an impaired phospholipid metabolism of the lysosome. Organs affected by phospholipidosis exhibit inflammatory reactions and histopathological changes. Despite significant advances in the understanding of drug-altered lipid metabolism, the relationship between impaired phospholipid metabolism and drug-induced toxicity remains enigmatic. Here we review molecular features of inheritable lysosomal storage disorders as a molecular mimicry of drug-induced phospholipidosis for an improved understanding of adverse drug reaction.