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RIFM fragrance ingredient safety assessment, 1-cyclohexylethyl butyrate, CAS Registry Number 63449-88-7

Short review
: Api, A.M.; Belsito, D.; Botelho, D.; Browne, D.; Bruze, M.; Burton, G.A.; Buschmann, Jochen; Calow, P.; Dagli, M.L.; Date, M.; Dekant, W.; Deodhar, C.; Fryer, A.D.; Joshi, K.; Cava, S. la; Lapczynski, A.; Liebler, D.C.; O'Brien, D.; Parakhia, R.; Patel, A.; Penning, T.M.; Ritacco, G.; Romine, J.; Salvito, D.; Schultz, T.W.; Sipes, I.G.; Thakkar, Y.; Tsang, S.; Wahler, J.


Food and Chemical Toxicology : FCT 110 (2017), Supplement 1, S.S160-S168
ISSN: 0278-6915
ISSN: 1873-6351
Fraunhofer ITEM ()
genotoxicity; repeated dose toxicity; developmental and reproductive toxicity; skin sensitization

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analogue d-cyclocitronellene acetate (CAS # 25225-10-9) show that this material does not have skin sensitization potential. The repeated dose, reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The developmental toxicity endpoint was completed using data from the target material which provided a MOE >100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.