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New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing

 
: Hoffmann, A.; Leonards, H.; Tobies, N.; Pongratz, L.; Kreuels, K.; Kreimendahl, F.; Apel, C.; Wehner, M.; Nottrodt, N.

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Volltext (PDF; )

Journal of tissue engineering : JTE 8 (2017), S.1-9
ISSN: 2041-7314
Englisch
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer ILT ()

Abstract
Stereolithography is one of the most promising technologies for the production of tailored implants. Within this study, we show the results of a new resin formulation for three-dimensional printing which is also useful for subsequent surface functionalization. The class of materials is based on monomers containing either thiol or alkene groups. By irradiation of the monomers at a wavelength of 266 nm, we demonstrated an initiator-free stereolithographic process based on thiol-ene click chemistry. Specimens made from this material have successfully been tested for biocompatibility. Using Fourier-transform infrared spectrometry and fluorescent staining, we are able to show that off-stoichiometric amounts of functional groups in the monomers allow us to produce scaffolds with functional surfaces. We established a new protocol to demonstrate the opportunity to functionalize the surface by copper-catalyzed azide-alkyne cycloaddition chemistry. Finally, we demonstrate a three-dimensional bioprinting concept for the production of potentially biocompatible polymers with thiol-functionalized surfaces usable for subsequent functionalization.

: http://publica.fraunhofer.de/dokumente/N-487444.html