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Towards a 21st-century roadmap for biomedical research and drug discovery: Consensus report and recommendations

 
: Langley, G.R.; Adcock, I.M.; Busquet, F.; Crofton, K.M.; Csernok, E.; Giese, C.; Heinonen, T.; Herrmann, K.; Hofmann-Apitius, M.; Landesmann, B.; Marshall, L.J.; McIvor, E.; Muotri, A.R.; Noor, F.; Schutte, K.; Seidle, T.; Stolpe, A. van de; Esch, H. van; Willett, C.; Woszczek, G.

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Drug Discovery Today 22 (2017), Nr.2, S.327-339
ISSN: 1359-6446
ISSN: 1878-5832
European Commission EC
FP7-HEALTH; 267038; NOTOX
Predicting long-term toxic effects using computer models based on systems characterization of organotypic cultures
Englisch
Zeitschriftenaufsatz
Fraunhofer SCAI ()

Abstract
Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies, and the corporate and non-governmental organisation (NGO) sectors, in this consensus report, we analyse, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathways-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this.

: http://publica.fraunhofer.de/dokumente/N-484753.html