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2017
Journal Article
Titel
High-antifouling polymer brush coatings on nonpolar surfaces via adsorption-cross-linking strategy
Abstract
A new ""adsorption-cross-linking"" technology is presented to generate a highly dense polymer brush coating on various nonpolar substrates, including the most inert and low-energy surfaces of poly(dimethyl siloxane)and poly(tetrafluoroethylene). This prospective surface modification strategy is based on a tailored bifunctional amphiphilic block copolymer with benzophenone units as the hydrophobic anchor/chemical cross-linker and terminal azide groups for in situ postmodification. The resulting polymer brushes exhibited long-term and ultralow protein adsorption and cell adhesion benefiting from the high density and high hydration ability of polyglycerol blocks. The presented antifouling brushes provided a highly stable and robust bioinert background for biospecific adsorption of desired proteins and bacteria after secondary modification with bioactive ligands, e.g., mannose for selective ConA and Escherichia coli binding.
Author(s)
Lu, Leixiao
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany
Hou, Yong
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany
Cheng, Chong
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany
Schlaich, Christoph
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany
Noeske, Paul-Ludwig Michael
Wei, Qiang
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany & Department of Cellular Biophysics, Max-Planck Institute for Medical Research, Heidelberg, Heisenbergstr. 3, 70569 Stuttgart, Germany & Multifunctional Biomaterials for Medicine, Helmholtz Virtual Institute, Kantstr. 55, 14513 Teltow-Seehof, Germany